Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
Journal of Korean Medical Science
;
: 979-982, 2006.
Article
in English
| WPRIM
| ID: wpr-134503
ABSTRACT
Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA Mutational Analysis
/
Biomarkers
/
Genetic Testing
/
Prevalence
/
Risk Factors
/
Bacteremia
/
Risk Assessment
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Toll-Like Receptor 2
Type of study:
Etiology study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2006
Type:
Article
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