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IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma
Allergy, Asthma & Immunology Research ; : 134-140, 2010.
Article in English | WPRIM | ID: wpr-134535
ABSTRACT

PURPOSE:

Aspirin-intolerant asthma (AIA) is characterized by moderate to severe asthma that is aggravated by aspirin or other non-steroidal anti-inflammatory drugs. Affected patients frequently have chronic rhinosinusitis and nasal polyposis due to persistent upper and lower airway inflammation with marked eosinophilia. IL-13 plays a crucial role in the development of allergic asthma by inducing airway eosinophilia and hyper-reactivity and it has been correlated with an increased eosinophil count.

METHODS:

Two promoter polymorphisms of the IL-13 gene (-1510 A>C and -1055C>T) and one coding nonsynonymus Arg110Gln (110G>A) polymorphism were genotyped using primer extension methods in 162 patients with AIA, 301 patients with aspirin-tolerant asthma (ATA), and 430 normal healthy controls (NC).

RESULTS:

There was no significant difference in the genotype, allele, and haplotype frequencies of the three polymorphisms among the three groups. AIA patients with the AA genotype -1510A>C (P=0.012) and CC genotype -1055C>T (PA).

CONCLUSIONS:

These findings suggest that the IL-13 polymorphisms at -1510A>C and 1055C>T are associated with the development of rhinosinusitis in AIA patients. IL-13 Arg110Gln may be associated with an increased eosinophil count and eotaxin-1 level and could increase eosinophilic inflammation in the upper and lower airways of patients with AIA.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Haplotypes / Aspirin / Interleukin-13 / Polymorphism, Single Nucleotide / Alleles / Eosinophilia / Eosinophils / Chemokine CCL11 / Clinical Coding Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Haplotypes / Aspirin / Interleukin-13 / Polymorphism, Single Nucleotide / Alleles / Eosinophilia / Eosinophils / Chemokine CCL11 / Clinical Coding Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2010 Type: Article