IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma
Allergy, Asthma & Immunology Research
;
: 134-140, 2010.
Article
in English
| WPRIM
| ID: wpr-134538
ABSTRACT
PURPOSE:
Aspirin-intolerant asthma (AIA) is characterized by moderate to severe asthma that is aggravated by aspirin or other non-steroidal anti-inflammatory drugs. Affected patients frequently have chronic rhinosinusitis and nasal polyposis due to persistent upper and lower airway inflammation with marked eosinophilia. IL-13 plays a crucial role in the development of allergic asthma by inducing airway eosinophilia and hyper-reactivity and it has been correlated with an increased eosinophil count.METHODS:
Two promoter polymorphisms of the IL-13 gene (-1510 A>C and -1055C>T) and one coding nonsynonymus Arg110Gln (110G>A) polymorphism were genotyped using primer extension methods in 162 patients with AIA, 301 patients with aspirin-tolerant asthma (ATA), and 430 normal healthy controls (NC).RESULTS:
There was no significant difference in the genotype, allele, and haplotype frequencies of the three polymorphisms among the three groups. AIA patients with the AA genotype -1510A>C (P=0.012) and CC genotype -1055C>T (PA).CONCLUSIONS:
These findings suggest that the IL-13 polymorphisms at -1510A>C and 1055C>T are associated with the development of rhinosinusitis in AIA patients. IL-13 Arg110Gln may be associated with an increased eosinophil count and eotaxin-1 level and could increase eosinophilic inflammation in the upper and lower airways of patients with AIA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Haplotypes
/
Aspirin
/
Interleukin-13
/
Polymorphism, Single Nucleotide
/
Alleles
/
Eosinophilia
/
Eosinophils
/
Chemokine CCL11
/
Clinical Coding
Limits:
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2010
Type:
Article
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