A Case of Gilbert's Syndrome with Severe Neonatal Hyperbilirubinemia
Journal of the Korean Society of Neonatology
;
: 266-269, 2010.
Article
in English
| WPRIM
| ID: wpr-134721
ABSTRACT
Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population has Gilbert's syndrome. Commonly, Gilbert's syndrome causes mild symptoms. However, a case of Gilbert's syndrome with severe neonatal hyperbilirubinemia is presented here. The patient developed jaundice three days after birth. Five days after birth, the patient's total serum bilirubin level was 34 mg/dL. The patient received intensive phototherapy and was given oral phenobarbital. Hemolytic hyperbilirubinemia was excluded on the basis of laboratory tests. Heterozygote polymorphisms of the promoter region (-3279T>G) and exon 1 (211G>A) were found in UGT1A1 gene. After discharge, the patient did not require any further treatment. This is the first case of proven Gilbert's syndrome with severe neonatal hyperbilirubinemia in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenobarbital
/
Phototherapy
/
Uridine Diphosphate
/
Bilirubin
/
Exons
/
Promoter Regions, Genetic
/
Glucuronosyltransferase
/
Parturition
/
Hyperbilirubinemia, Neonatal
/
Gilbert Disease
Limits:
Humans
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of the Korean Society of Neonatology
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS