Does Pre-Treatment with High Dose Atorvastatin Prevent Microvascular Dysfunction after Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome?
Korean Circulation Journal
;
: 472-480, 2016.
Article
in English
| WPRIM
| ID: wpr-134750
ABSTRACT
BACKGROUND AND OBJECTIVES:
There is controversy surrounding whether or not high dose statin administration before percutaneous coronary intervention (PCI) decreases peri-procedural microvascular injury. We performed a prospective randomized study to investigate the mechanisms and effects of pre-treatment high dose atorvastatin on myocardial damage in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing PCI. SUBJECTS ANDMETHODS:
Seventy seven patients with NSTE-ACS were randomly assigned to either the high dose group (atorvastatin 80 mg loading 12 to 24 h before PCI with a further 40 mg loading 2 h before PCI, n=39) or low dose group (atorvastatin 10 mg administration 12 to 24 h before PCI, n=38). Index of microcirculatory resistance (IMR) was measured after stent implantation. Creatine kinase-myocardial band (CK-MB) and high sensitivity C-reactive protein (CRP) levels were measured before and after PCI.RESULTS:
The baseline characteristics were not different between the two patient groups. Compared to the low dose group, the high dose group had lower post PCI IMR (14.1±5.0 vs. 19.2±9.3 U, p=0.003). Post PCI CK-MB was also lower in the high dose group (median 1.40 ng/mL (interquartile range [IQR 0.75 to 3.45] vs. 4.00 [IQR 1.70 to 7.37], p=0.002) as was the post-PCI CRP level (0.09 mg/dL [IQR 0.04 to 0.16] vs. 0.22 [IQR 0.08 to 0.60], p=0.001).CONCLUSION:
Pre-treatment with high dose atorvastatin reduces peri-PCI microvascular dysfunction verified by post-PCI IMR and exerts an immediate anti-inflammatory effect in patients with NSTE-ACS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
C-Reactive Protein
/
Stents
/
Prospective Studies
/
Angioplasty
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Creatine
/
Acute Coronary Syndrome
/
Percutaneous Coronary Intervention
/
Atorvastatin
/
Microcirculation
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS