Significance of Changes of Tumor Necrosis Factor-alpha in Blood and Urine as a Early Diagnostic Tool of Acute Rejection in Renal Allograft / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 235-240, 1997.
Article
in Korean
| WPRIM
| ID: wpr-13480
ABSTRACT
This is a report of 51 cases in renal allograft, which were treated at the Yeungnam University Hospital from February 1994 to July 1996 and compared the significance of changes of TNF-alpha in blood and urine as a diagnostic tool of acute rejection in renal allograft. The aim of this study was to investigate the value of plasma and urinary TNF-alpha in patients with renal allografts. Renal allografts divided them into four groups (control, acute rejection, acute tubular necrosis and systemic infection) that obtained plasma and urinary TNF-alpha. The sampling day of blood and urine in each group were as follows in control group at the day of transplantation and postoperative 1, 5, 7 days respectively, in acute rejection group at before the day of initiation of therapy and the 1, 3 days after therapy, in acute tubular necrosis group at the day of low urine output and the 4 subsequent days, and in systemic infection group at the day of diagnosis and the 3 subsequent days. The results were as follows Plasma TNF-alpha levels were significantly elevated in 68.4% (p0.05). In contrast, urinary TNF-alpha were detected in acute rejection group (42.1%, p<0.01) and acute tubular necrosis group (20.0%, p<0.05). Control and systemic infection groups were not detectable in urinary TNF-alpha. The results suggested that plasma and urinary TNF-alpha may be used as the complementary diagnostic tool of acute rejection in renal allograft patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Tumor Necrosis Factor-alpha
/
Diagnosis
/
Allografts
/
Necrosis
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Transplantation
Year:
1997
Type:
Article
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