A Study on the Number of Circulating CD4+CD25+Foxp3+ Regulatory T Cells and CD4+CD25-Foxp3+ T Cells in Psoriasis / 대한피부과학회지
Korean Journal of Dermatology
;
: 270-276, 2015.
Article
in Korean
| WPRIM
| ID: wpr-135067
ABSTRACT
BACKGROUND:
Regulatory T cells (Treg) are able to inhibit the immunological response and maintain cutaneous immunological homeostasis, thus preventing autoimmunity against itself. In several studies, the importance of CD4+CD25+Foxp3+ Treg in psoriasis has been examined, using the peripheral blood of patients. However, limited studies on Treg are available and shows conflicting results. Recently, CD4+CD25-Foxp3+ T cells were identified as being the peripheral reservoir of CD4+CD25+Foxp3+ Treg.OBJECTIVE:
The purpose of this study was to investigate differences in the CD4+CD25+Foxp3+ Treg and CD4+CD25- Foxp3+ T cell counts between patients with psoriasis and normal controls.METHODS:
For phenotypic analysis, the proportions and absolute cell numbers of CD4+CD25+Foxp3+ Treg and CD4+CD25-Foxp3+ T cells in the peripheral blood were examined by flow cytometry. The correlation between the CD4+CD25+Foxp3+ Treg count and other parameters (age of onset, disease duration, BSA, psoriasis area and severity index score, and clinical stage) was also analyzed.RESULTS:
Although the CD4+CD25+Foxp3+ Treg count was slightly increased while the number of CD4+CD25- Foxp3+ T cells was slightly decreased in psoriasis patients than that of the controls, the differences between the groups were not statistically significant (5.27+/-2.60 vs. 4.70+/-1.35, p>0.05; 1.56+/-1.07 vs. 1.93+/-1.08, p>0.05). The CD4+CD25+Foxp3+ Treg count did not correlate with the tested parameters except for the clinical stage of psoriasis. The mean+/-SD number of CD4+CD25+Foxp3+ Treg in the stable phase was higher than that in the progressive phase (7.26+/-2.58 vs. 4.35+/-2.10, p0.05).CONCLUSION:
These findings suggest that the CD4+CD25+Foxp3+ Treg count alone is insufficient to explain the pathogenesis and severity of psoriasis. However, a decrease in circulating CD4+CD25+Foxp3+ Treg is likely to be correlated with an aggravation of psoriasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
T-Lymphocytes
/
Autoimmunity
/
Cell Count
/
T-Lymphocytes, Regulatory
/
Flow Cytometry
/
Homeostasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2015
Type:
Article
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