Antiplaque and antigingivitis effects of a mouthrinse containing cetylpyridinium chloride, triclosan and dipotassium glycyrrhizinate
Journal of Periodontal & Implant Science
;
: 33-38, 2012.
Article
in English
| WPRIM
| ID: wpr-135245
ABSTRACT
PURPOSE:
The goal of this study was to evaluate the clinical anitplaque and antigingivitis effects of a mouthrinse containing cetylpyridinium chloride (CPC), triclosan and dipotassium glycyrrhizinate (DPZ) in patients with gingivitis and mild periodontitis.METHODS:
Thirty-two subjects were randomized into 2 groups. The test group used a mouthrinse containing 0.05% CPC, 0.02% triclosan and 0.02% DPZ, while the control group used a placebo mouthrinse. At baseline, 2 weeks and 4 weeks, the papillary bleeding index (PBI), Turesky-Quigley-Hein plaque index (PI) and Loe-Silness gingival index (GI) were assessed. During the experimental period, the patients used the mouthrinse for 30 seconds, 4 to 5 times/day (10 mL/time) within 30 minutes after toothbrushing.RESULTS:
No adverse effects appeared in either the experimental or the control group. Regarding PBI, PI and GI values, statistical significance was detected between values at baseline and 2 weeks for both groups (P<0.05). In the experimental group, statistically significantly lower values were detected at 4 weeks compared to at 2 weeks. However, in the control group, no statistically significant difference was detected between the values at 2 weeks and 4 weeks. Additionally, the mean value after 4 weeks for the control group was slightly higher than the mean value after 2 weeks for the control group.CONCLUSIONS:
This study for 4 weeks demonstrated that mouthrinses containing CPC, triclosan and DPZ may contribute to the reduction of supragingival plaque and gingivitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sulfates
/
Triclosan
/
Dinucleoside Phosphates
/
Cetylpyridinium
/
Periodontal Index
/
Dental Plaque Index
/
Citrates
/
Zinc Compounds
/
Glycyrrhizic Acid
/
Drug Combinations
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2012
Type:
Article
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