Association of the dopamine transporter gene with Parkinson's disease in Korean patients
Journal of Korean Medical Science
;
: 449-451, 2000.
Article
in English
| WPRIM
| ID: wpr-135350
ABSTRACT
Dopamine transporters (DAT) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (MPP) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. The association of a variable number tandem repeat polymorphism in the DAT gene with Parkinson's disease (PD) in a Korean population was studied. The 10-copy allele was the most common, accounting for 77.2+ACU- and 81.6+ACU- of alleles in PD patients and control subjects, respectively. The rare 11-copy allele was more common in the patients (odds ratio +AD0- 2.5, 95+ACU- confidence interval +AD0- 1.1-5.7, p+ADw-0.02). It is suggested that the 11-copy allele of the DAT gene may confer susceptibility to PD for some patients in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Comparative Study
/
Carrier Proteins
/
Case-Control Studies
/
Odds Ratio
/
Genetic Predisposition to Disease
/
Alleles
/
Gene Frequency
/
Genotype
/
Korea
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2000
Type:
Article
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