Chronological effects of atherogenic diets on the aorta, liver and spleen of rabbits
Journal of Korean Medical Science
;
: 413-419, 2000.
Article
in English
| WPRIM
| ID: wpr-135359
ABSTRACT
To investigate the temporal progression of atherogenesis on the aorta and involvement of the monocyte-macrophage system in the liver and spleen, we fed 74 rabbits with high fat (14 or 7 gm+ACU-) and cholesterol (2 and 1+ACU-) diets for 4 to over 24 weeks. Using both light and electron microscopies, we found that the bro-fatty areas on the luminal surface of aortas was spread over along the eding time dependently. The fat deposits also in the liver and spleen worsened pending on the time of feeding the atherogenic diets. Not only nocyte-derived foam cells, but also parenchymatous cells in the liver and leen involved become fat-laden cells. According to these results, we propose at there are three stages 1) the primary seeding, 2) the intermediate turing and 3) the advanced periods. These periods may play very important les in designing the management and treatment of atherosclerotic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Aortic Diseases
/
Arteriosclerosis
/
Spleen
/
Splenic Diseases
/
Time Factors
/
Cholesterol, Dietary
/
Dietary Fats
/
Microscopy, Electron
/
Dose-Response Relationship, Drug
Limits:
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2000
Type:
Article
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