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Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
Journal of Pathology and Translational Medicine ; : 32-39, 2017.
Article in English | WPRIM | ID: wpr-13606
ABSTRACT

BACKGROUND:

Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea.

METHODS:

AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues.

RESULTS:

AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001).

CONCLUSIONS:

AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphotransferases / Prognosis / Immunohistochemistry / Colorectal Neoplasms / Adenocarcinoma / Proportional Hazards Models / Gene Amplification / Multivariate Analysis / In Situ Hybridization / Disease-Free Survival Type of study: Prognostic study Limits: Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Pathology and Translational Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphotransferases / Prognosis / Immunohistochemistry / Colorectal Neoplasms / Adenocarcinoma / Proportional Hazards Models / Gene Amplification / Multivariate Analysis / In Situ Hybridization / Disease-Free Survival Type of study: Prognostic study Limits: Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Pathology and Translational Medicine Year: 2017 Type: Article