Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
Yonsei Medical Journal
;
: 188-191, 2011.
Article
in English
| WPRIM
| ID: wpr-136367
ABSTRACT
Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs > or = 0.5 microg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon suggests that neither evolution nor spread of any significant QRDRs mutations in clinical isolates occurred in Korea. Therefore, continued surveillance is necessary to observe the evolution of antibiotic-resistance and take measures to avoid the spread of drug-resistant clones.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ofloxacin
/
Microbial Sensitivity Tests
/
Haemophilus influenzae
/
DNA Topoisomerases, Type II
/
DNA Gyrase
/
Korea
/
Anti-Bacterial Agents
/
Mutation
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2011
Type:
Article
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