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Alterations of epinephrine-induced gluconeogenesis in aging
Experimental & Molecular Medicine ; : 334-340, 2009.
Article in English | WPRIM | ID: wpr-136586
ABSTRACT
The effects of glucagon and epinephrine on gluconeogenesis in young (4 month) and old (24 month) Fisher 344 rat hepatocytes were compared. In contrast to glucagon, which had a similar effect on gluconeogenesis in both young and old cells, epinephrine caused a smaller increase in gluconeogenesis in old rat hepatocytes than in young hepatocytes. beta2 adrenergic receptor (beta2-AR) expression slightly decreased in aged rat liver, and there were differences between young and old hepatocytes in their patterns of G protein coupled receptor kinases, which are involved in the activation of beta2-AR receptor signal desensitization. The major isoform of the kinase changed from GRK2 to GRK3 and the expression of beta-arrestin, which is recruited by the phosphorylated beta2-AR for internalization and degradation, increased in aged rat liver. GRK3 overexpression also decreased the glucose output from young rat hepatocytes. We conclude that an age-associated reduction in epinephrine-induced gluconeogenesis occurs through the epinephrine receptor desensitizing system.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorylation / Rats, Inbred F344 / Aging / Glucagon / Epinephrine / Receptors, Adrenergic, beta-2 / Adrenergic beta-Agonists / G-Protein-Coupled Receptor Kinase 2 / G-Protein-Coupled Receptor Kinase 3 / Gluconeogenesis Type of study: Prognostic study Limits: Animals Language: English Journal: Experimental & Molecular Medicine Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorylation / Rats, Inbred F344 / Aging / Glucagon / Epinephrine / Receptors, Adrenergic, beta-2 / Adrenergic beta-Agonists / G-Protein-Coupled Receptor Kinase 2 / G-Protein-Coupled Receptor Kinase 3 / Gluconeogenesis Type of study: Prognostic study Limits: Animals Language: English Journal: Experimental & Molecular Medicine Year: 2009 Type: Article