Secondary Cutaneous Follicular B-Cell Lymphoma Associated with Erythematous Swelling on the Leg: A Case Report / 대한피부과학회지
Korean Journal of Dermatology
;
: 364-368, 2017.
Article
in Korean
| WPRIM
| ID: wpr-136698
ABSTRACT
Cutaneous follicular B-cell lymphoma (CFBCL) is defined as the neoplastic proliferation of germinal center cells confined to the skin. Secondary CFBCL demonstrates a more aggressive clinical course compared to the primary form. We report the case of a 45-year-old man who presented with a 15-day history of lesions on his right leg. Clinical examination revealed multiple erythematous miliary/agminated papules on the right proximal thigh with erythematous swollen patches on the right lower leg. Biopsy of a thigh lesion revealed a massive dermal lymphocytic infiltrate with a follicular pattern. Immunohistochemical staining revealed atypical lymphocytes, which strongly expressed CD20, CD10, Bcl-2, Bcl-6 and Ki-67 proteins, but not CD3 and Cyclin D1. Additionally, further studies revealed that this cutaneous lesion had originated from a retroperitoneal lymph node. We treated the patient with systemic chemotherapy using a cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone (CHOP) regimen and anti-CD20 monoclonal antibodies. This case illustrates a rarely reported example of secondary cutaneous follicular B-cell lymphoma showing peculiar clinical manifestations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Thigh
/
Vincristine
/
Biopsy
/
Prednisone
/
B-Lymphocytes
/
Lymphocytes
/
Lymphoma, B-Cell
/
Germinal Center
/
Cyclin D1
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2017
Type:
Article
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