Effects of intraoperative continuous infusion of low dose remifentanil and intravenous bolus dose of fentanyl on postoperative pain
Anesthesia and Pain Medicine
;
: 138-142, 2011.
Article
in English
| WPRIM
| ID: wpr-136953
ABSTRACT
BACKGROUND:
The aim of this study was to evaluate whether continuous infusion of remifentanil during propofol anesthesia could produce opioid-induced hyperalgesia (OIH) and whether an intravenous bolus of fentanyl could control OIH in the management of postoperative pain.METHODS:
One hundred fifty-nine women undergoing gynecologic surgery were randomly divided into four groups. Group C nitrous oxide and propofol infusion (3-4 microg/ml, n = 40), Group F propofol infusion and intravenous bolus administration of fentanyl (1 microg/kg) after suturing the peritoneum (n = 40), Group R propofol and remifentanil infusion (2-4 ng/ml, n = 40) and Group RF propofol, remifentanil infusion and intravenous bolus administration of fentanyl (n = 39). Patient controlled analgesia was started after the operation. The postoperative visual analog scale (VAS) was measured in the recovery room, then at 2 h, 6 h, 12 h, and 24 h after the operation.RESULTS:
The VAS scores for Groups R and F in the recovery room were lower than for group C (P < 0.05), but there were no differences 2 h after the operation. The VAS scores for Group RF 6 h and 12 h after the operation were higher than those for group C (P < 0.05).CONCLUSIONS:
Our results suggest that low dose (2-4 ng/ml) continuous infusion of remifentanil during propofol anesthesia does not produce marked hyperalgesia. However, an intravenous bolus of fentanyl can aggravate OIH induced by remifentanil.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Peritoneum
/
Piperidines
/
Recovery Room
/
Gynecologic Surgical Procedures
/
Propofol
/
Fentanyl
/
Analgesia, Patient-Controlled
/
Hyperalgesia
/
Anesthesia
Limits:
Female
/
Humans
Language:
English
Journal:
Anesthesia and Pain Medicine
Year:
2011
Type:
Article
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