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Effect of RAAS Inhibition on the Incidence of Cancer and Cancer Mortality in Patients with Glomerulonephritis
Journal of Korean Medical Science ; : 59-66, 2011.
Article in English | WPRIM | ID: wpr-137390
ABSTRACT
Angiotensin II type 1 receptor blocker (ARB), which is frequently prescribed in patients with glomerulonephritis (GN), is suggested to increase the risk of cancer. We registered 3,288 patients with renal biopsy and analyzed the relationship between the use of renin-angiotensin-aldosterone system (RAAS) blockade and the incidence of cancer or cancer mortality. After renal biopsy, cancer developed in 33 patients with an incidence rate of 1.0% (95% of CI for incidence 0.7%-1.3%). There was no difference in the cancer incidence among the groups according to the use of angiotensin-converting enzyme inhibitors (ACEI) or ARB 1.2% in the None (23/1960), 0.7% in the ARB-only (5/748), 0.4% in the ACEI-only (1/247), and 1.2% in the ACEI-ARB (4/333) (P = 0.487) groups. The cancer mortality was 2.1%, 0.4%, 0.0%, and 0.3% in None, ACEI-only, ARB-only, and ACEI-ARB group, respectively (P < 0.001). The risk of cancer mortality in patients with ARB was only 0.124 (0.034-0.445) compared to that of non-users of ARB by Cox's hazard proportional analysis. In conclusion, prescription of ACEI or ARB in patients with GN does not increase cancer incidence and recipients of ARB show rather lower rates of all-cause mortality and cancer mortality.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Renin-Angiotensin System / Angiotensin-Converting Enzyme Inhibitors / Incidence / Retrospective Studies / Risk Factors / Follow-Up Studies / Angiotensin II Type 1 Receptor Blockers / Glomerulonephritis / Kidney / Neoplasms Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Renin-Angiotensin System / Angiotensin-Converting Enzyme Inhibitors / Incidence / Retrospective Studies / Risk Factors / Follow-Up Studies / Angiotensin II Type 1 Receptor Blockers / Glomerulonephritis / Kidney / Neoplasms Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article