The Incidence of Serious Infection among Rheumatoid Arthritis Patients Exposed to Tumor Necrosis Factor Antagonists / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 246-253, 2010.
Article
in Korean
| WPRIM
| ID: wpr-137464
ABSTRACT
OBJECTIVE:
We wanted to investigate the incidence of serious infections among the rheumatoid arthritis (RA) patients who were treated with tumor necrosis factor alpha (TNF-alpha) antagonists.METHODS:
We enrolled the 175 RA patients who were treated with TNF-alpha antagonists for at least 3 months during February 2003 to July 2008, and these patients were in the SMART-b cohort of Kangnam St. Mary's hospital. Patients were prescribed infliximab, etanercept or adalimumab. The data was retrospectively collected.RESULTS:
The incidence of serious infections among the RA patients treated with TNF-alpha was significantly increased according to the survival analysis, as compared with that of those patient treated with conventional DMARDs (p<0.01). The most common serious infection was pneumonia. There was no significant difference in the incidence of serious infections among the three TNF-alpha antagonists used in this study (p=0.96). But the serious infections occurred more often in the patients who received more than 10 mg methotrexate (MTX) per week (p=0.02).CONCLUSION:
RA patients treated with TNF-alpha antagonists had a higher incidence of serious infection. Therefore, close monitoring for serious infection is needed for RA patients who are receiving TNF-alpha antagonists.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Arthritis, Rheumatoid
/
Immunoglobulin G
/
Methotrexate
/
Incidence
/
Retrospective Studies
/
Cohort Studies
/
Tumor Necrosis Factor-alpha
/
Receptors, Tumor Necrosis Factor
/
Antirheumatic Agents
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2010
Type:
Article
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