Protective Effects of Trimetazidine in a Rabbit Model of Transient Spinal Cord Ischemia / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 255-260, 2002.
Article
in Korean
| WPRIM
| ID: wpr-137721
ABSTRACT
BACKGROUND:
Paraplegia remains unresolved as the most dreaded operative complication with surgical treatment of descending thoracic and thoracoabdominal aortic diseases. In this study, the neuroprotective effect of trimetazidine that has been used clinically for ischemic heart disease was investigated in a rabbit spinal cord ischemia model. MATERIAL ANDMETHOD:
Thirty-three New Zealand white rabbits were randomized as follows control group undergoing abdominal aortic occlusion but receiving no pharmacologic intervention(Group 1, n=17); TMZ group(Group 2, n=16) receiving 3 mg/kg trimetazidine intravenously before the occlusion of the aorta. Ischemia was induced by clamping the abdominal aorta just distal to the left renal artery for 30 minutes. Neurologic status was assessed at 2, 24, and 48 hours after the operation according to the modified Tarlov scale, then the lumbosacral spinal cord was processed for histopathologic examinations 48 hours after the final assessment.RESULT:
The average motor function score was significantly higher in the TMZ group(3.20 +/- 0.77 vs 1.13 +/- 1.25 at 2 hours, 3.50 +/- 0.76 vs 1.45 +/- 1.57 at 24 hours, and 3.91 +/- 0.30 vs 1.86 +/- 1.86 at 48 hours after operation; p value
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Aorta, Abdominal
/
Aortic Diseases
/
Paraplegia
/
Renal Artery
/
Spinal Cord
/
Spinal Cord Injuries
/
Trimetazidine
/
Myocardial Ischemia
/
Neuroprotective Agents
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2002
Type:
Article
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