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Changes in High Levels of 17 alpha-Hydroxyprogesterone at Neonatal Screening / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology ; : 156-161, 2003.
Article in Korean | WPRIM | ID: wpr-138145
ABSTRACT

PURPOSE:

There are some cases of false positive in neonatal screening for congenital adrenal hyperplasia. To understand its significance of the increased 17 alpha-hydroxyprogesterone(17 alpha-OHP) levels in the cases of positive result, we followed its levels during infancy.

METHODS:

From July 1997 to June 1998, totally 1,730 babies were screened for congenital adrenal hyperplasia(CAH) measuring 17 alpha-hydroxyprogesterone(17 alpha- OHP) using an enzyme immunoassay(EIA) on dried blood spots. In infants of positive result, the radioimmunoassay(RIA) was used measuring 17 alpha-OHP in serum. And we followed up the levels of 17 alpha-OHP during infancy. Cortisol and ACTH were also measured and followed up in the morning simultaneously.

RESULTS:

No CAH was detected during the study period. With the 13 ng/mL cutoff limit for 17 alpha-OHP before March 1998, the recall rate was 3.09%. With the 20 ng/mL cutoff limit after March 1998, the recall rate was decreased to 1.58%. Follow-up of the high levels of 17 alpha-OHP in positive cases showed a sharply decreased curve according to age.

CONCLUSION:

In clinically normal neonates, the high levels of 17 alpha-OHP at screening decreased continuously during infancy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Hydrocortisone / Mass Screening / Follow-Up Studies / Neonatal Screening / Adrenal Hyperplasia, Congenital / Adrenocorticotropic Hormone / 17-alpha-Hydroxyprogesterone Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Humans / Infant / Infant, Newborn Language: Korean Journal: Journal of Korean Society of Pediatric Endocrinology Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Hydrocortisone / Mass Screening / Follow-Up Studies / Neonatal Screening / Adrenal Hyperplasia, Congenital / Adrenocorticotropic Hormone / 17-alpha-Hydroxyprogesterone Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Humans / Infant / Infant, Newborn Language: Korean Journal: Journal of Korean Society of Pediatric Endocrinology Year: 2003 Type: Article