Changes in High Levels of 17 alpha-Hydroxyprogesterone at Neonatal Screening / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 156-161, 2003.
Article
in Korean
| WPRIM
| ID: wpr-138145
ABSTRACT
PURPOSE:
There are some cases of false positive in neonatal screening for congenital adrenal hyperplasia. To understand its significance of the increased 17 alpha-hydroxyprogesterone(17 alpha-OHP) levels in the cases of positive result, we followed its levels during infancy.METHODS:
From July 1997 to June 1998, totally 1,730 babies were screened for congenital adrenal hyperplasia(CAH) measuring 17 alpha-hydroxyprogesterone(17 alpha- OHP) using an enzyme immunoassay(EIA) on dried blood spots. In infants of positive result, the radioimmunoassay(RIA) was used measuring 17 alpha-OHP in serum. And we followed up the levels of 17 alpha-OHP during infancy. Cortisol and ACTH were also measured and followed up in the morning simultaneously.RESULTS:
No CAH was detected during the study period. With the 13 ng/mL cutoff limit for 17 alpha-OHP before March 1998, the recall rate was 3.09%. With the 20 ng/mL cutoff limit after March 1998, the recall rate was decreased to 1.58%. Follow-up of the high levels of 17 alpha-OHP in positive cases showed a sharply decreased curve according to age.CONCLUSION:
In clinically normal neonates, the high levels of 17 alpha-OHP at screening decreased continuously during infancy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Hydrocortisone
/
Mass Screening
/
Follow-Up Studies
/
Neonatal Screening
/
Adrenal Hyperplasia, Congenital
/
Adrenocorticotropic Hormone
/
17-alpha-Hydroxyprogesterone
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Humans
/
Infant
/
Infant, Newborn
Language:
Korean
Journal:
Journal of Korean Society of Pediatric Endocrinology
Year:
2003
Type:
Article
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