Fermented antler extract enhances the viability and interleukin-12 production of spleen cells
Korean Journal of Veterinary Research
;
: 183-187, 2016.
Article
in Korean
| WPRIM
| ID: wpr-13822
ABSTRACT
The effects of antlers have long been known in traditional Asian medicine. However, few studies have investigated the effects of antlers on immunity. In this study, we investigated whether fermented antler extract (FAE) has immunomodulatory effects on spleen cells. FAE enhanced the activity of spleen cells in a concentration dependent manner compared to antler extract. Interestingly, FAE significantly increased the production of interleukin-12, a representative cytokine of cell-mediated immunity, while it marginally increased that of tumor necrosis factor-alpha. Flow cytometry analysis demonstrated that FAE can protect spleen cells from spontaneous cell death without a significant proportional change in subsets, mainly lymphocytes. Taken together, the results of the present study showed that FAE has beneficial effects on spleen cells, a major type of immune cell, indicating that it can function as an immunomodulator without significant cytotoxicity. These data may broaden the use of FAE in basic research and clinical areas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antlers
/
Spleen
/
Lymphocytes
/
Tumor Necrosis Factor-alpha
/
Cell Death
/
Interleukin-12
/
Asian People
/
Immunomodulation
/
Flow Cytometry
/
Immunity, Cellular
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Veterinary Research
Year:
2016
Type:
Article
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