Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
The Korean Journal of Internal Medicine
;
: 505-513, 2017.
Article
in English
| WPRIM
| ID: wpr-138425
ABSTRACT
BACKGROUND/AIMS:
There may be an association between vitamin D levels and allograft outcomes in kidney transplant recipients (KTRs). However, few studies have been conducted to determine the association between vitamin D levels and post-transplant infections. This study investigated the impact of vitamin D deficiency on the risk of infection after kidney transplantation.METHODS:
We measured 25-hydroxyvitamin D (25(OH)D) levels prior to kidney transplantation. Vitamin D deficiency was defined as a serum 25(OH)D level < 20 ng/mL. We examined the incidence of various post-transplant infections during follow-up period. We used Cox proportional hazards regression analysis to determine factors associated with increased risk of post-transplant infections during the follow-up period.RESULTS:
A total of 164 KTRs were followed up for a mean of 24.8 ± 10.7 months. Among them, 135 patients (82.3%) had vitamin D deficiency. Patients with vitamin D deficiency had a significantly higher incidence of urinary tract infection (p = 0.027) and any bacterial infection (p = 0.010) compared to those without vitamin D deficiency. Vitamin D deficiency was not significantly associated with incidence of viral or fungal infections. Cox proportional hazards regression analysis revealed that vitamin D deficiency (hazard ratio, 11.07; 95% confidence interval, 1.46 to 84.03; p = 0.020) was independent risk factor for post-transplant bacterial infections.CONCLUSIONS:
Pre-transplant vitamin D deficiency was a significant risk factor for bacterial infections after kidney transplantation. Further studies are needed on possible benefits of vitamin D supplementation for preventing post-transplant bacterial infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacterial Infections
/
Urinary Tract Infections
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Incidence
/
Risk Factors
/
Follow-Up Studies
/
Kidney Transplantation
/
Allografts
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2017
Type:
Article
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