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Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy
The Korean Journal of Internal Medicine ; : 443-451, 2017.
Article in English | WPRIM | ID: wpr-138439
ABSTRACT
BACKGROUND/

AIMS:

Approximately 30% of esophageal cancer (EC) patients cannot complete endoscopic ultrasonography (EUS) due to malignant stricture (EUS non-traversability). This study examines clinical implications of EUS non-traversability in patients with advanced locoregional squamous EC receiving preoperative chemoradiotherapy (CRT) followed by esophagectomy.

METHODS:

We retrieved data on 89 consecutive patients with advanced locoregional squamous EC (stage II or III). Relevant clinical and tumor-specific parameters were reviewed retrospectively. Significant factors affecting survival was determined by Cox regression analysis.

RESULTS:

EUS non-traversable EC was observed in 26 of 89 patients (29.2%). Median serum albumin level (3.6 g/dL vs. 3.9 g/dL, p = 0.028), tumor length (6.0 cm vs. 4.0 cm, p = 0.002), and percentage of clinical stage III disease (65.4% vs. 38.1%, p = 0.019) were significantly different between the patients with EUS non-traversable and traversable EC, respectively. Patients with EUS non-traversable EC demonstrated a significantly lower 5-year overall survival than patients with EUS traversable EC (30.8% vs. 49.3%, p = 0.023). In multivariate analysis, weight loss ≥ 10% (p = 0.033), EUS non-traversability (p = 0.003), non-response to preoperative CRT (p = 0.002), and incompletion of esophagectomy (p = 0.002) were significant negative factors of survival.

CONCLUSIONS:

EUS non-traversability has significant negative prognostic implications in patients with advanced locoregional squamous EC receiving preoperative CRT followed by esophagectomy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Serum Albumin / Esophageal Neoplasms / Carcinoma, Squamous Cell / Weight Loss / Multivariate Analysis / Retrospective Studies / Esophagectomy / Constriction, Pathologic / Endosonography Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: The Korean Journal of Internal Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Serum Albumin / Esophageal Neoplasms / Carcinoma, Squamous Cell / Weight Loss / Multivariate Analysis / Retrospective Studies / Esophagectomy / Constriction, Pathologic / Endosonography Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: The Korean Journal of Internal Medicine Year: 2017 Type: Article