Nucleolar organizer regions of lymphomas in Korea
Journal of Korean Medical Science
;
: 99-105, 1988.
Article
in English
| WPRIM
| ID: wpr-138483
ABSTRACT
Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells and which possess ribosomal RNA (rRNA) genes. The numbers and/or configurations of NORs have been thought to be related to cellular activities. To assess the applicability of NORs associated protein (Ag-NORs) in the field of diagnostic histopathology, a silver staining was done in paraffin sections of malignant lymphomas, tonsils and reactive lymph nodes and the numbers of Ag-NORs in the nuclei of low-grade and those of high-grade lymphomas were compared. A significant difference was found between the numbers of Ag-NORs in the nuclei of low-grade lymphoma (a mean of 1.3 per nucleus) and those of high-grade lymphomas (a mean of 4.2 to 8.3 per nucleus). The Ag-NORs were often observed in nuclei in areas where nucleoli themselves were not visible in H and E stain. It is suggested that this method would be of great value in the field of tumor histopathology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Silver
/
Staining and Labeling
/
Lymphoma, Non-Hodgkin
/
Histological Techniques
/
Korea
/
Nucleolus Organizer Region
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1988
Type:
Article
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