Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a
Biomolecules & Therapeutics
;
: 41-46, 2014.
Article
in English
| WPRIM
| ID: wpr-138512
ABSTRACT
Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells. In the current study, the antiviral activity of hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that hederasaponin B and 30% ethanol extract of Hedera helix containing hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.These results suggest that hederasaponin B and Hedera helix extract containing hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vero Cells
/
Blotting, Western
/
Enterovirus
/
Hedera
/
Capsid Proteins
/
Ethanol
/
Hand, Foot and Mouth Disease
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2014
Type:
Article
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