Your browser doesn't support javascript.
loading
Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin
Biomolecules & Therapeutics ; : 35-40, 2014.
Article in English | WPRIM | ID: wpr-138515
ABSTRACT
Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Biological Products / Pigmentation / Alpha-MSH / Monophenol Monooxygenase / Hyperpigmentation / Vitis / Microphthalmia-Associated Transcription Factor / Fruit / Guinea Pigs Limits: Animals Language: English Journal: Biomolecules & Therapeutics Year: 2014 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Biological Products / Pigmentation / Alpha-MSH / Monophenol Monooxygenase / Hyperpigmentation / Vitis / Microphthalmia-Associated Transcription Factor / Fruit / Guinea Pigs Limits: Animals Language: English Journal: Biomolecules & Therapeutics Year: 2014 Type: Article