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Prevention of Hepatitis B reactivation in the setting of immunosuppression
Clinical and Molecular Hepatology ; : 219-237, 2016.
Article in English | WPRIM | ID: wpr-138553
ABSTRACT
Advances in the treatment of malignant and inflammatory diseases have developed over time, with increasing use of chemotherapeutic and immunosuppressive agents of a range of drug classes with varying mechanism and potency in their effects on the immune system. These advances have been met with the challenge of increased risk of hepatitis B virus (HBV) reactivation in susceptible individuals. The magnitude of risk of HBV reactivation is associated with the individual's HBV serological status and the potency and duration of immunosuppression. Individuals with chronic hepatitis B (CHB) and previously infected but serologically cleared HBV infection are both susceptible to HBV reactivation. HBV reactivation in the setting of immunosuppression is a potentially life threatening condition leading to liver failure and death in extreme cases. It is important to recognize that HBV reactivation in the setting of immunosuppression is potentially preventable. Therefore, identification of patients at risk of HBV reactivation and institution of prophylactic antiviral therapy prior to initiation of immunosuppression is essential.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Autoimmune Diseases / Virus Activation / Hepatitis B virus / Organ Transplantation / Hematopoietic Stem Cell Transplantation / Hepatitis B / Hepatitis B Core Antigens / Hepatitis B Surface Antigens / Immunosuppressive Agents Limits: Humans Language: English Journal: Clinical and Molecular Hepatology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Autoimmune Diseases / Virus Activation / Hepatitis B virus / Organ Transplantation / Hematopoietic Stem Cell Transplantation / Hepatitis B / Hepatitis B Core Antigens / Hepatitis B Surface Antigens / Immunosuppressive Agents Limits: Humans Language: English Journal: Clinical and Molecular Hepatology Year: 2016 Type: Article