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From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers / 대한해부학회지
Anatomy & Cell Biology ; : 73-78, 2012.
Article in English | WPRIM | ID: wpr-138736
ABSTRACT
Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is known to be associated with radio/chemo-resistance and metastasis that eventually lead to cancer progression contributing to poor prognosis in cancer patients. Among transcription factors that accumulated under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has received the most intense attention in this field of research due to its capacity to modulate several hundred genes. With a clearer understanding of the HIF-1 pathway, efforts are directed at manipulation of this complex genetic process in order to ultimately decrease cellular HIF-1 levels. Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxygen / Prognosis / Transcription Factors / Genetic Phenomena / Hypoxia / Neoplasm Metastasis Type of study: Prognostic study Limits: Humans Language: English Journal: Anatomy & Cell Biology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxygen / Prognosis / Transcription Factors / Genetic Phenomena / Hypoxia / Neoplasm Metastasis Type of study: Prognostic study Limits: Humans Language: English Journal: Anatomy & Cell Biology Year: 2012 Type: Article