An Association Study between Various Adrenergic Alpha 2 Receptor Polymorphisms and Treatment Response to Mirtazapine in Major Depression
Journal of Korean Geriatric Psychiatry
;
: 20-26, 2010.
Article
in Korean
| WPRIM
| ID: wpr-139204
ABSTRACT
OBJECTIVES:
Genetic differences may contribute to the inter-individual differences in treatment response to antidepressants among patients suffering from major depression. This study investigated a possible association of treatment response to mirtazapine with various adrenergic alpha 2 receptor polymorphisms in major depressive patients.METHODS:
A 6-week naturalistic treatment study with a blinded outcome examined 84 Korean patients with major depression. Treatment response to mirtazapine was defined as > or =50% decrease in HAM-D scores at six weeks. In this study, four genetic polymorphisms were selected ; ADRA2A MspI, ADRA2A DraI, alpha2BDel301-303, and alpha2CDel322-325.RESULTS:
The Del/Del genotype of alpha2CDel322-325 exhibited a significant association with response to mirtazapine through multiple logistic regression. ADRA2A DraI, alpha2BDel301-303, and alpha2CDel322-325 did not showed a significant association with response to mirtazapine.CONCLUSION:
Based on the finding that alpha2CDel322-325 polymorphism had an association with the mirtazapine response, we postulate that the polymorphism related to the mechanism of the antidepressant effect is important in predicting the response to antidepressants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacogenetics
/
Polymorphism, Genetic
/
Stress, Psychological
/
Logistic Models
/
Receptors, Adrenergic
/
Polymorphism, Single Nucleotide
/
Depression
/
Genotype
/
Mianserin
/
Antidepressive Agents
Type of study:
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Geriatric Psychiatry
Year:
2010
Type:
Article
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