Clinical Implication of Galectin-1 Expression in Human Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
;
: 36-40, 2006.
Article
in Korean
| WPRIM
| ID: wpr-140336
ABSTRACT
PURPOSE:
The role of different galectins in the pathogenesis of different types of malignancy is now being intensely investigated. In this study, authors investigated the level of galectin-1 expression in human breast cancer tissue to define its relationship to the tumor invasiveness and tumor progression.METHODS:
Formalin-fixed, paraffin-embedded tissues from 79 randomly selected breast cancer patients were used to perform immunohistochemical staining for galectin-1. The primary antibody was diluted mouse monoclonal antibody against galectin-1. The staining results were then interpreted by an experienced pathologist, and the results were compared between the groups having different pathologic variables.RESULTS:
In breast cancer patients, galectin-1 was diversely expressed in the cancer tissue. Galectin-1 was expressed in both cancer cells and cancer-associated stromal cells. The levels of galectin-1 expression in cancer-associated stromal cells were higher in patients with invasive carcinoma (p = 0.001), in patients with advanced T stages (p = 0.007), and in patients with advanced TNM stages (p = 0.007). The galectin-1 expression in cancer-associated stromal cells was also higher in patients with lymph node metastasis and advanced N stages, but did not reach a statistically significant level. The galectin-1 expression in cancer cell did not have any correlation with pathologic variables.CONCLUSION:
This is the first study that has demonstrated the relationship of galectin-1 expression with the tumor invasiveness and tumor progression in human breast cancer. Further large-scaled studies are needed to define the prognostic value of galectin-1 in breast cancer patients, and the exact role of galectin-1 should be investigated more thoroughly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Neoplasms
/
Immunohistochemistry
/
Stromal Cells
/
Galectins
/
Galectin 1
/
Lymph Nodes
/
Neoplasm Invasiveness
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of Breast Cancer
Year:
2006
Type:
Article
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