Analysis of Aqueous Humor Cytokines in Diabetic Retinopathy
Journal of the Korean Ophthalmological Society
;
: 1821-1827, 2014.
Article
in Korean
| WPRIM
| ID: wpr-140802
ABSTRACT
PURPOSE:
To investigate the relationship between the concentration of aqueous humor cytokines and the severity of diabetic retinopathy.METHODS:
Thirty-six subjects were included in the control, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR) groups, each group has 12 patients. Aqueous levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha) were investigated according to the severity of diabetic retinopathy.RESULTS:
When the control group was compared with the PDR and NPDR groups, aqueous levels of IL-6 were significantly higher in PDR patients than in those of both the control and NPDR groups (p = 0.016 and p = 0.003, respectively). The aqueous levels of VEGF were significantly higher in the eyes of PDR patients than in those of the control group (p = 0.003). There were no statistically significant differences between the 3 groups with regard to other cytokines.CONCLUSIONS:
Aqueous levels of IL-6 and VEGF were higher in the eyes of PDR patients than in those of healthy controls.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aqueous Humor
/
Monocytes
/
Cytokines
/
Interleukin-8
/
Interferons
/
Interleukin-4
/
Interleukin-6
/
Interleukin-2
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2014
Type:
Article
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