Microchimerism of Fetal Origin in Ovarian Tissues from Women with Pelvic Endometriosis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1506-1512, 2005.
Article
in Korean
| WPRIM
| ID: wpr-14100
ABSTRACT
OBJECTIVE:
To investigate whether fetal microchimeric cells were detected in ovarian tissues with pelvic endometriosis.METHODS:
Ovarian tissues with endometriosis were obtained from five women who had at least one live-born son and who underwent enucleation of endometriotic cyst or oophorectomy after a diagnosis of endometriotic cyst. Control tissues were obtained from five women with endometriosis who had no pregnant history. Tissue sections were analyzed with fluorescence in situ hybridization for the presence of fetal cells, defined by X and Y chromosome.RESULTS:
Fluorescence in situ hybridization using paraffin-embedded ovarian specimens was performed successfully. Male cells were found in ovarian tissues from all five patients. No male cells were found in ovarian tissues from all five controls.CONCLUSION:
Fetal microchimeric cells, possibly from feto-maternal cell trafficking were detected in ovarian tissues with endometriosis were obtained from women who had prior male pregnancies. Further study is necessary to understand the role of persistent fetal microchimeric cells in the progression of endometriosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Y Chromosome
/
Ovariectomy
/
In Situ Hybridization
/
Chimerism
/
Diagnosis
/
Endometriosis
/
Fluorescence
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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