Your browser doesn't support javascript.
loading
Clinical Remission of Renal Amyloidosis after Autologous Peripheral Blood Stem Cell Transplantation / 이화의대지
The Ewha Medical Journal ; : S25-S29, 2013.
Article in English | WPRIM | ID: wpr-141198
ABSTRACT
Primary amyloidosis has unfavorable prognosis, particularly with organ involvement. Here, we report a case of clinical remission of renal amyloidosis after autologous hematopoietic cell transplantation. A 51-year-old female patient visited our hospital due to generalized edema. Initial evaluation showed hyperlipidemia, hypoalbuminemia, and heavy proteinuria, which were consistent with nephrotic syndrome. However, IgM lamda type monoclonal gammopathy was detected in serum and urine electrophoresis studies. Renal biopsy showed Congo red-positive amyloid deposition in mesangial area, glomerular capillary walls, and arterioles and amyloid fibers were confirmed by electron microscopy. Immunohistochemial study of the biopsy tissue demonstrated systemic light-chain amyloidosis (AL amyloidosis). Multiple myeloma was not evident on bone marrow examination. She received autologous hematopoietic cell transplantation after high dose melphalan treatment. Complete remissions were achieved after the treatment, respectively. Our findings suggest the potential role of autologous peripheral blood stem cell transplantation in treatment of AL amyloidosis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Paraproteinemias / Arterioles / Prognosis / Proteinuria / Biopsy / Bone Marrow Examination / Immunoglobulin M / Capillaries / Microscopy, Electron / Cell Transplantation Type of study: Prognostic study Limits: Female / Humans Country/Region as subject: Africa Language: English Journal: The Ewha Medical Journal Year: 2013 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Paraproteinemias / Arterioles / Prognosis / Proteinuria / Biopsy / Bone Marrow Examination / Immunoglobulin M / Capillaries / Microscopy, Electron / Cell Transplantation Type of study: Prognostic study Limits: Female / Humans Country/Region as subject: Africa Language: English Journal: The Ewha Medical Journal Year: 2013 Type: Article