Clinical Remission of Renal Amyloidosis after Autologous Peripheral Blood Stem Cell Transplantation / 이화의대지
The Ewha Medical Journal
;
: S25-S29, 2013.
Article
in English
| WPRIM
| ID: wpr-141198
ABSTRACT
Primary amyloidosis has unfavorable prognosis, particularly with organ involvement. Here, we report a case of clinical remission of renal amyloidosis after autologous hematopoietic cell transplantation. A 51-year-old female patient visited our hospital due to generalized edema. Initial evaluation showed hyperlipidemia, hypoalbuminemia, and heavy proteinuria, which were consistent with nephrotic syndrome. However, IgM lamda type monoclonal gammopathy was detected in serum and urine electrophoresis studies. Renal biopsy showed Congo red-positive amyloid deposition in mesangial area, glomerular capillary walls, and arterioles and amyloid fibers were confirmed by electron microscopy. Immunohistochemial study of the biopsy tissue demonstrated systemic light-chain amyloidosis (AL amyloidosis). Multiple myeloma was not evident on bone marrow examination. She received autologous hematopoietic cell transplantation after high dose melphalan treatment. Complete remissions were achieved after the treatment, respectively. Our findings suggest the potential role of autologous peripheral blood stem cell transplantation in treatment of AL amyloidosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraproteinemias
/
Arterioles
/
Prognosis
/
Proteinuria
/
Biopsy
/
Bone Marrow Examination
/
Immunoglobulin M
/
Capillaries
/
Microscopy, Electron
/
Cell Transplantation
Type of study:
Prognostic study
Limits:
Female
/
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
The Ewha Medical Journal
Year:
2013
Type:
Article
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