Optimal Effect-Site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway Removal during Emergence
Yonsei Medical Journal
;
: 529-534, 2015.
Article
in English
| WPRIM
| ID: wpr-141606
ABSTRACT
PURPOSE:
This randomized, controlled, double-blind study was designed to determine the optimal dose of remifentanil for preventing complications associated with the removal of a laryngeal mask airway (LMA) without delaying emergence. MATERIALS ANDMETHODS:
This study randomly assigned 128 patients to remifentanil effect-site concentrations (Ce) of 0 ng/mL (group R0), 0.5 ng/mL (group R0.5), 1.0 ng/mL (group R1.0), and 1.5 ng/mL (group R1.5) during emergence. The emergence and recovery profiles were recorded. Adverse events such as coughing, airway obstruction, breath-holding, agitation, desaturation, nausea, and vomiting were also evaluated.RESULTS:
The number of patients with respiratory complications such as coughing and breath-holding was significantly lower in the R1.0 and R1.5 groups than in the R0 group (p<0.05). Emergence agitation also decreased in the R1.0 and R1.5 groups (p<0.0083). The time to LMA removal was significantly longer in the R1.5 group than in the other groups (p<0.05).CONCLUSION:
Maintaining a remifentanil Ce of 1.0 ng/mL during emergence may suppress adverse events such as coughing, breath-holding, and agitation following the removal of LMA without delayed awakening.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Postoperative Complications
/
Psychomotor Agitation
/
Vomiting
/
Infusions, Intravenous
/
Anesthesia Recovery Period
/
Double-Blind Method
/
Laryngeal Masks
/
Anesthetics, Intravenous
/
Cough
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2015
Type:
Article
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