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Depiction of Acute Stroke Using 3-Tesla Clinical Amide Proton Transfer Imaging: Saturation Time Optimization Using an in vivo Rat Stroke Model, and a Preliminary Study in Human
Investigative Magnetic Resonance Imaging ; : 65-70, 2017.
Article in English | WPRIM | ID: wpr-141830
ABSTRACT

PURPOSE:

To optimize the saturation time and maximizing the pH-weighted difference between the normal and ischemic brain regions, on 3-tesla amide proton transfer (APT) imaging using an in vivo rat model. MATERIALS AND

METHODS:

Three male Wistar rats underwent middle cerebral artery occlusion, and were examined in a 3-tesla magnetic resonance imaging (MRI) scanner. APT imaging acquisition was performed with 3-dimensional turbo spin-echo imaging, using a 32-channel head coil and 2-channel parallel radiofrequency transmission. An off-resonance radiofrequency pulse was applied with a Sinc-Gauss pulse at a B(1,rms) amplitude of 1.2 µT using a 2-channel parallel transmission. Saturation times of 3, 4, or 5 s were tested. The APT effect was quantified using the magnetization-transfer-ratio asymmetry at 3.5 ppm with respect to the water resonance (APT-weighted signal), and compared with the normal and ischemic regions. The result was then applied to an acute stroke patient to evaluate feasibility.

RESULTS:

Visual detection of ischemic regions was achieved with the 3-, 4-, and 5-s protocols. Among the different saturation times at 1.2 µT power, 4 s showed the maximum difference between the ischemic and normal regions (-0.95%, P = 0.029). The APTw signal difference for 3 and 5 s was -0.9% and -0.7%, respectively. The 4-s saturation time protocol also successfully depicted the pH-weighted differences in an acute stroke patient.

CONCLUSION:

For 3-tesla turbo spin-echo APT imaging, the maximal pH-weighted difference achieved when using the 1.2 µT power, was with the 4 s saturation time. This protocol will be helpful to depict pH-weighted difference in stroke patients in clinical settings.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Protons / Brain / Magnetic Resonance Imaging / Water / Rats, Wistar / Stroke / Infarction, Middle Cerebral Artery / Models, Animal / Head Type of study: Practice guideline Limits: Animals / Humans / Male Language: English Journal: Investigative Magnetic Resonance Imaging Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Protons / Brain / Magnetic Resonance Imaging / Water / Rats, Wistar / Stroke / Infarction, Middle Cerebral Artery / Models, Animal / Head Type of study: Practice guideline Limits: Animals / Humans / Male Language: English Journal: Investigative Magnetic Resonance Imaging Year: 2017 Type: Article