Survival Analysis of the Children with Down Syndrome / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 338-344, 1999.
Article
in Korean
| WPRIM
| ID: wpr-14191
ABSTRACT
OBJECTIVE:
To determine the life expectancy and causes of death of the children with Down syndrome(DS), longitudinal follow-up study was done for 29 cases of DS who were born at CHA hospital located in Seoul During the period from July 1991 to Dec. 1994.METHODS:
29 cases were divided into groups according to the presence of congenital heart disease (CHD) and leukemia. CHD group was subdivided into DS with complete AVSD(atrioventricular septal defect) and DS without complete AVSD. Survival curves were calculated by kaplan-Meier product limit method. Each group were compared by log rank test. The factors affecting mortality rate were analyzed by Cox's proportional hazard regressional model.RESULTS:
There were no statistical differences in mortality rate between groups with CHD(35.3%) and without CHD(33.3%)(p=0.7373). Statistical difference was not observed between CHD subgroups with AVSD and with CHD other than AVSD. There were significant statistical difference in mortality rate between groups with leukemia and without leukemia(p=0.0001).CONCLUSION:
The factor affecting mortality rate of DS was the presence of leukemia regardless of presence of CHD in our study cases with DS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia
/
Survival Analysis
/
Follow-Up Studies
/
Life Expectancy
/
Mortality
/
Cause of Death
/
Down Syndrome
/
Kaplan-Meier Estimate
/
Seoul
/
Heart Defects, Congenital
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Perinatology
Year:
1999
Type:
Article
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