Transforming growth factor-beta and the glomerular filtration barrier
Kidney Research and Clinical Practice
;
: 3-10, 2013.
Article
in English
| WPRIM
| ID: wpr-142118
ABSTRACT
The increasing burden of chronic kidney disease worldwide and recent advancements in the understanding of pathologic events leading to kidney injury have opened up new potential avenues for therapies to further diminish progression of kidney disease by targeting the glomerular filtration barrier and reducing proteinuria. The glomerular filtration barrier is affected by many different metabolic and immune-mediated injuries. Glomerular endothelial cells, the glomerular basement membrane, and podocytes-the three components of the filtration barrier-work together to prevent the loss of protein and at the same time allow passage of water and smaller molecules. Damage to any of the components of the filtration barrier can initiate proteinuria and renal fibrosis. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine strongly associated with the fibrogenic response.It has a known role in tubulointerstitial fibrosis. In this review we will highlight what is known about TGF-beta and how it interacts with the components of glomerular filtration barrier and causes loss of function and proteinuria.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteinuria
/
Fibrosis
/
Water
/
Transforming Growth Factor beta
/
Endothelial Cells
/
Glomerular Basement Membrane
/
Podocytes
/
Renal Insufficiency, Chronic
/
Glomerular Filtration Barrier
/
Filtration
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2013
Type:
Article
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