Proliferative Effect of Retinal Glial Cells by Growth Factors
Journal of the Korean Ophthalmological Society
;
: 1179-1187, 1997.
Article
in Korean
| WPRIM
| ID: wpr-14245
ABSTRACT
The authors tried to evaluate the effect of the growth factors on cell proliferation in the human retina astrocyte culture. Each growth factor, EGF, bFGF, GGF, IGF-1 or PDGF, together with BrdU was added to astrocytes-enriched cultures in the serum-free media. The proliferating effect of each growth factor was evaluated by a double immunofluo- rescenece labelling for GFAP and BrdU. By and addition of each growth factor, the number of retinal astrocytes at the synthetic stage significantly increased than those of control group (p<0.01). In comparision, PDGF was more potent than IGF-1 (p<0.01). Above data extended the concept of astrocytic proliferation caused by several growth factors in human retinal injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retina
/
Retinaldehyde
/
Bromodeoxyuridine
/
Insulin-Like Growth Factor I
/
Neuroglia
/
Astrocytes
/
Culture Media, Serum-Free
/
Intercellular Signaling Peptides and Proteins
/
Cell Proliferation
/
Epidermal Growth Factor
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
1997
Type:
Article
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