Immunohistochemical Study for the Syndecan-1, E-cadher in and Beta-catenin Expressions in Epidermal Tumors / 대한피부과학회지
Korean Journal of Dermatology
;
: 309-317, 2011.
Article
in Korean
| WPRIM
| ID: wpr-142667
ABSTRACT
BACKGROUND:
Syndecan-1, E-cadherin and beta-catenin are cell adhesion molecules that are primarily expressed on the surface of adult epithelial cells. The expressions of them appear to be inversely correlated with tumor aggressiveness and invasiveness.OBJECTIVE:
The purpose of this study was to investigate the expressions of syndecan-1, E-cadherin and beta-catenin in tissue sections of normal sun-damaged skin, cutaneous premalignant lesions and squamous cell carcinoma in all stages of the evolution of lesions associated with sun exposure.METHODS:
Ten normal skins from patients with actinic keratosis, 10 cases of seborrheic keratosis, 5 cases of actinic keratosis, 5 cases of Bowen's disease, 5 cases of keratoacanthoma without dysplatic cells, 5 cases of keratoacanthoma with dysplastic cells in an invasive margin, 5 cases of poor-differentiated squqmous cell carcinoma and 5 cases of acantholytic squamous cell carcinoma were investigated. The specimens were assessed for the syndecan-1, E-cadherin and beta-catenin expressions using a semi-quantitative method in which the intensity of membranous staining was evaluated.RESULTS:
In almost all the cases the expression of the E-cadherin and beta-catenin was very similar. These adhesion molecules were progressively reduced in the epidermis of normal sun-damaged skin through premalignant lesions to squamous cell carcinoma. Also, the expression of syndecan-1 was similar to the E-cadherin and beta-catenin expressions except for a normal expression in premalignant lesions. But all three adhesion molecules were diminished with decreasing cell differentiation.CONCLUSION:
Our results suggest that syndecan-1, E-cadherin and beta-catenin are expressed similarly in the epithelium, and that the decreased expression of these adhesion molecules is associated with malignant transformation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Bowen's Disease
/
Carcinoma, Squamous Cell
/
Cadherins
/
Cell Adhesion Molecules
/
Solar System
/
Keratosis, Seborrheic
/
Epidermis
/
Epithelial Cells
/
Epithelium
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2011
Type:
Article
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