Characteristics and Follow-up Results of the Window Period Blood Donors for Hepatitis C Virus / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 15-22, 2007.
Article
in Korean
| WPRIM
| ID: wpr-14269
ABSTRACT
BACKGROUND:
To improve the safety of the blood supply in Korea, nucleic acid amplification testing (NAT) for HCV and HIV-1 as a blood screening test has been used by the Korean Red Cross since February 1st, 2005. Until October 31st 2006, a total of 4,037,618 donor samples had been tested and 436 cases showed reactivity for HCV RNA. Only 10 of these cases showed serologically negative antibody results.METHODS:
We investigated the characteristics and the follow-up results of the ten donors who showed HCV RNA reactivity and serologically negative results.RESULTS:
All the ten donors were identified to be "window period" blood donors with confirmation of their seroconversion by follow-up testing. The average RNA titer of the donors was 9.21x106 IU/mL. Five donors showed high levels of ALT. One donor showed the reversed pattern on the test results for antibody and RNA.CONCLUSION:
By detecting five cases of HCV "window period" infection, NAT has increased the safety of the Korean blood supply. But it is considered that NAT can not be a substitute serological test and an adequate follow-up strategy is required for verification of the accurate seroconversion time.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Red Cross
/
Tissue Donors
/
Blood Donors
/
RNA
/
Serologic Tests
/
Mass Screening
/
Follow-Up Studies
/
HIV-1
/
Hepatitis C
/
Hepacivirus
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2007
Type:
Article
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