Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation
Yonsei Medical Journal
;
: 1461-1467, 2016.
Article
in English
| WPRIM
| ID: wpr-143171
ABSTRACT
PURPOSE:
Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. MATERIALS ANDMETHODS:
This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression.RESULTS:
Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a.CONCLUSION:
Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biogenic Amines
/
Cell Differentiation
/
Central Nervous System
/
MicroRNAs
/
Agmatine
/
Cell Proliferation
/
Neurogenesis
/
Neural Stem Cells
/
Neurons
Language:
English
Journal:
Yonsei Medical Journal
Year:
2016
Type:
Article
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