Levels of Soluble Interleukin-2 Receptors in Serum of Patients with Behçet's Disease
Annals of Dermatology
;
: 13-16, 1993.
Article
in English
| WPRIM
| ID: wpr-143591
ABSTRACT
BACKGROUND:
Interleukin-2 receptor (IL-2) is expressed and released predominantly activated T lymphocyte. Increased serum levels of soluble IL-2R have been noted in a variety of autoimmune diseases and in conditions associated with T lymphocyte activation.OBJECTIVE:
We aimed to examine whether the T lymphocyte activation has any association with the pathogenesis of Behçet's disease.METHOD:
We have measured the serum level of soluble IL-2R in serum samples obtained from 67 patients with Behçet's disease and 30 healthy people as a control group, using a double-antibody sandwich enzyme-linked immunosorbent assay technique.RESULTS:
Serum soluble IL-2R levels were found to be significantly elevated in the group of Behçet's disease as compared with the control group. No significant differences were found within clinical subtypes of Behçet's disease.CONCLUSION:
These findings suggest the presence of an ongoing T lymphocyte activation in this disease process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Enzyme-Linked Immunosorbent Assay
/
Lymphocyte Activation
/
Lymphocytes
/
Receptors, Interleukin-2
/
Interleukin-2
/
Methods
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
1993
Type:
Article
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