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The Degree of Diabetic Retinopathy in Patients with Type 2 Diabetes Correlates with the Presence and Severity of Coronary Heart Disease
Article in En | WPRIM | ID: wpr-143611
Responsible library: WPRO
ABSTRACT
Both diabetic retinopathy (DR) and coronary heart disease (CHD) are clinically significant in diabetic patients. We investigated the correlation between the severity of DR and the presence and severity of CHD among type 2 diabetic patients. A total of 175 patients who were examined at the DR clinic and underwent dual-source computed tomography (DSCT) angiography within 6 months were included. The degree of DR was graded as no DR, nonproliferative DR (NPDR), and proliferative DR (PDR). The severity of CHD and the numbers of significant stenotic coronary artery on DSCT angiography according to DR grade were assessed. The mean Agatston Calcium Score (ACS) in patients with PDR was significantly higher than other groups (P < 0.001). The overall odds of an ACS increase were about 4.7-fold higher in PDR group than in no DR group (P < 0.001). In PDR group, in comparison with in no DR, the odds of having 1 or 2 arterial involvement were 3-fold higher (P = 0.044), and those of having 3 were 17-fold higher (P = 0.011). The c-index, one of the predictability values in regression analysis model, was not significantly increased when PDR was added to classical CHD risk factors (0.671 to 0.706, P = 0.111). Conclusively, patients with PDR develop a greater likelihood of not only having CHD, but being more severe nature. PDR has no additional effect to classical CHD risk factors for predicting CHD.
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Full text: 1 Index: WPRIM Main subject: Severity of Illness Index / Coronary Artery Disease / Angiography / Tomography, X-Ray Computed / Linear Models / Odds Ratio / Risk Factors / Coronary Vessels / Diabetes Mellitus, Type 2 / Diabetic Retinopathy Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Journal of Korean Medical Science Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Severity of Illness Index / Coronary Artery Disease / Angiography / Tomography, X-Ray Computed / Linear Models / Odds Ratio / Risk Factors / Coronary Vessels / Diabetes Mellitus, Type 2 / Diabetic Retinopathy Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Journal of Korean Medical Science Year: 2016 Type: Article