Association of Exercise-Induced Asthma with Atopy in Adult Patients with Asthma-Like Symptoms / 대한내과학회지
Korean Journal of Medicine
;
: 723-728, 2011.
Article
in Korean
| WPRIM
| ID: wpr-143844
ABSTRACT
BACKGROUND/AIMS:
Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms.METHODS:
Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine bronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded.RESULTS:
Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p = 0.007) and atopy (85.7% vs. 47.4, p = 0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5 +/- 3.0 vs. 6.5 +/- 2.0, p = 0.011), atopy index (2.1 +/- 0.3 vs. 1.0 +/- 0.3, p = 0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p = 0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p = 0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR] 14.3, 95% confidence interval [CI] 1.86-109.4) and atopy (OR 16.9, 95% CI 2.04-140.74) were significant risk factors for EIA.CONCLUSIONS:
Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pollen
/
Asthma
/
Asthma, Exercise-Induced
/
Skin
/
Allergens
/
Risk Factors
/
Methacholine Chloride
/
Bronchial Hyperreactivity
/
Pyroglyphidae
/
Dermatophagoides farinae
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2011
Type:
Article
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