Chromosomal Aberration in Fractionated Radiotherapy / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology
;
: 115-123, 1998.
Article
in Korean
| WPRIM
| ID: wpr-144135
ABSTRACT
PURPOSE:
This study was tried to evaluate the effect of the partial body fractionated irradiation on the frequency of chromosomal aberration. MATERIALS ANDMETHODS:
In three patients with uterine cervix carcinoma, chromosomal aberrations were analyzed during fractionated external beam radiotherapy. Radiation field included whole pelvis and total dose was 5040 cGy in 28 fractions.RESULTS:
The values of the frequency of dicentrics and rings (Ydr) in pre- irradiated peripheral lymphocytes in three patients were 0.0060, 0.0000, and 0.0029, respectively. The frequency of dicentrics and rings, estimated during the course of radiotherapy, increased with radiation dose and best fitted to the linear equation, Ydr=7.31x10(-5) D(cGy)+1.45x10(-2). The frequency of dicentrics and rings among the cells with dicentric and/or ring (Qdr) also showed increasing tendency and best fitted to the linear equation, Qdr= 1.01x10(-4) D(cGy)+1.04.CONCLUSION:
Ydr increased linearly with radiation dose in the dose range of our study, and Qdr showed increasing tendency with dose.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pelvis
/
Radiotherapy
/
Lymphocytes
/
Cervix Uteri
/
Chromosome Aberrations
Limits:
Female
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Therapeutic Radiology and Oncology
Year:
1998
Type:
Article
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