Effects of Intravesical Instillation of Cyclooxygenase-2 Inhibitor on Cyclophosphamide-induced Overactive Bladder / 대한비뇨기과학회지
Korean Journal of Urology
;
: 1241-1245, 2004.
Article
in Korean
| WPRIM
| ID: wpr-144329
ABSTRACT
PURPOSE:
This study was performed to investigate the effects of intravesical instillation of cyclooxygenase-2 (COX-2) inhibitors on the cyclophosphamide-induced overactive bladder. MATERIALS ANDMETHODS:
The 40 Sprague-Dawley rats were divided into 3 groups; the control group, the overactive group, and the COX-2 inhibitor treated group. Cystometrograms (CMG) were performed and the contraction interval, inter-contraction interval, contraction time and contraction pressure were measured. After CMG, the bladders of each group were dissected out, and weighed.RESULTS:
On CMG, the contraction interval and inter-contraction interval for the overactive group were significantly decreased compared with the control group. After treatment with COX-2 inhibitor, the contraction interval and inter-contraction interval were significantly increased compared with the overactive group (p<0.05). The contraction time in the overactive group was significantly increased compared with the control group, and it was also decreased in the COX-2 inhibitor treated group compared with the overactive group (p<0.05). The contraction pressure in the overactive group and the COX-2 inhibitor treated group were significantly increased compared with the control group. There were no significant differences between the overactive and COX-2 inhibitor treated groups. The bladder weights of the overactive and COX-2 inhibitor treated groups were significantly increased compared with the control group (p<0.05).CONCLUSIONS:
Intravesical instillation of COX-2 inhibitor can suppress cyclophosphamide-induced detrusor overactivity. Therefore, intravesical instillation of COX-2 inhibitor may be considered as a possible treatment for the overactive bladder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Weights and Measures
/
Urinary Bladder
/
Administration, Intravesical
/
Rats, Sprague-Dawley
/
Cyclophosphamide
/
Cyclooxygenase 2
/
Cyclooxygenase 2 Inhibitors
/
Urinary Bladder, Overactive
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2004
Type:
Article
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