Trimethyltin-Induced Hippocampal Neurodegeneration is Possibly Mediated by Induction of Apoptosis
Journal of the Korean Neurological Association
;
: 861-868, 1999.
Article
in Korean
| WPRIM
| ID: wpr-144406
ABSTRACT
BACKGROUND:
Trimethyltin (TMT) is a neurotoxicant which produces a distinct pattern of neuronal cell death in the hippocampus following systemic administration of a single dose. However, the mechanism of selective neuronal death remains unclear. We performed this study to elucidate the underlying mechanism of TMT-induced hippocampal neu-ronal death.METHODS:
The effects of trimethyltin (8.0mg/kg, I.p., single dose) on the hippocampal neurons were investi-gated in terms of changes in the neurobehavioral status, histologic, and electron microscopc findings.RESULTS:
Behaviorally, TMT treatment caused stereotypic limbic system dysfunction, i.e. tremors, spontaneous seizures, vocaliza-tion, hyperactivity, hyperexcitability, intraspecific aggression as described previously. Morphologically, TMT produced prominent neurodegeneration in the dentate gyrus. Widespread, strong glial fibrillary acidic protein (GFAP) immunore-activity, which was suggestive of reactive astrogliosis, was noted throughout the hippocampal subfields. Many degener-ating neurons were TUNEL positive. Electron microscopic findings revealed characteristic features of apoptosis in the dentate granule cells. NADPH-diaphorase positive cells were spared after TMT exposure.CONCLUSIONS:
It is suggested that TMT-induced hippocampal degeneration might be a useful in vivo model for the study of learning and memory, neuronal-glial interactions, and selective neuronal apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Tremor
/
Cell Death
/
Apoptosis
/
Dentate Gyrus
/
In Situ Nick-End Labeling
/
Aggression
/
Glial Fibrillary Acidic Protein
/
Hippocampus
/
Learning
Type of study:
Prognostic study
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1999
Type:
Article
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