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Occurrence of diabetic ketoacidosis and autoimmune thyroiditis in a patient treated with pegylated interferon-alpha 2b and ribavirin for chronic hepatitis C / 대한간학회지
The Korean Journal of Hepatology ; : 187-191, 2010.
Article in Korean | WPRIM | ID: wpr-14480
ABSTRACT
Combined pegylated interferon and ribavirin therapy for chronic hepatitis C infection cause a wide range of side effects, including flu-like syndrome, hematological abnormalities, cardiovascular symptoms, gastrointestinal symptoms, pulmonary dysfunction, depression, and retinopathy. Interferon-alpha has been shown to be related to the development of various autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroid disease, and type 1 diabetes mellitus (DM). Type 1 DM and thyroid disease respectively develop in 0.08~2.61% and 10~15% of patients treated with combined interferon-alpha and ribavirin for chronic hepatitis C. The coexistence of type 1 DM and autoimmune thyroiditis was rarely reported. We report a case of a 33-year-old female patient with chronic hepatitis C who simultaneously developed diabetic ketoacidosis and autoimmune thyroiditis after treatment with pegylated interferon-alpha 2b and ribavirin.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Polyethylene Glycols / Ribavirin / Thyroxine / Thyroiditis, Autoimmune / Interferon-alpha / Diabetic Ketoacidosis / Hepatitis C, Chronic / Drug Therapy, Combination / Insulin Limits: Adult / Female / Humans Language: Korean Journal: The Korean Journal of Hepatology Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Polyethylene Glycols / Ribavirin / Thyroxine / Thyroiditis, Autoimmune / Interferon-alpha / Diabetic Ketoacidosis / Hepatitis C, Chronic / Drug Therapy, Combination / Insulin Limits: Adult / Female / Humans Language: Korean Journal: The Korean Journal of Hepatology Year: 2010 Type: Article