Pro-apoptotic function of hepatitis B virus X protein / 대한간학회지
The Korean Journal of Hepatology
; : 112-122, 2010.
Article
in Ko
| WPRIM
| ID: wpr-14489
Responsible library:
WPRO
ABSTRACT
Infection of hepatitis B virus (HBV) is a main cause of liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Among the HBV-encoded proteins, the HBV X protein (HBx) has been suspected to be strongly involved in HBV-associated liver pathogenesis. HBx, a virally encoded multifunctional regulator, has been shown to induce apoptosis, anti-apoptosis, proliferation, and transformation of cells depending on the cell lines, model systems used, assay protocols, and research groups. Among the several activities of HBx, the pro-apoptotic function of HBx will be discussed in this review. Given that the disruption of apoptosis pathway by HBx contributes to the liver pathogenesis, a better understanding of the molecular interference in the cellular pro-apoptotic networks by HBx will provide useful clues for the intervention in HBV-mediated liver diseases.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Trans-Activators
/
Tumor Suppressor Protein p53
/
Apoptosis
/
Tumor Necrosis Factors
/
Hepatitis B
/
Liver Diseases
Type of study:
Prognostic_studies
Language:
Ko
Journal:
The Korean Journal of Hepatology
Year:
2010
Type:
Article