Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 446-449, 2010.
Article
in English
| WPRIM
| ID: wpr-145232
ABSTRACT
BACKGROUND:
Pain at the site of rocuronium injection is a common side-effect in pediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combination of nitrous oxide and lidocaine pretreatment on withdrawal response during rocuronium injection in children.METHODS:
Sixty six pediatric patients, ages 5 to 12 years, were randomly assigned to two groups. The oxygen group received 100% oxygen, and the nitrous oxide group received 50% N2O in oxygen over 2 min. After anesthesia was induced with 2.5% thiopental sodium 5 mg/kg and manual occlusion of the forearm was performed, 1% lidocaine 1 mg/kg was injected over 15 sec. After the occlusion was released, 0.1% rocuronium 0.6 mg/kg was injected over 5 sec. Patient response to rocuronium injection was graded using a 4-point scale.RESULTS:
Overall incidence of withdrawal movements was significantly lower in the nitrous oxide group (1 patients; 3.1%) than in the oxygen group (8 patients; 25.8%) (P = 0.013). No patient in the nitrous oxide group displayed arm or generalized movement (grade 3 or 4) associated with rocuronium injection.CONCLUSIONS:
This study demonstrated that a combination of inhaled 50% N2O in O2 and 1 mg/kg lidocaine pretreatment significantly reduced the incidence of rocuronium-induced withdrawal movements in pediatric patients compared with lidocaine pretreatment alone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Arm
/
Thiopental
/
Double-Blind Method
/
Incidence
/
Prospective Studies
/
Forearm
/
Androstanols
/
Anesthesia
/
Lidocaine
Type of study:
Controlled clinical trial
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2010
Type:
Article
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