Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 435-439, 2010.
Article
in English
| WPRIM
| ID: wpr-145234
ABSTRACT
BACKGROUND:
Microemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine.METHODS:
One hundred twenty patients aged between 20-65 years old were allocated randomly into one of three groups (n = 40, in each). The patients in the remifentanil group received remifentanil 0.5 microgram/kg IV for 30 seconds before a microemulsion propofol injection. The patients in the lidocaine group received propofol 2 mg/kg premixed with 40 mg lidocaine over a 60 second period. The patients in the combination group received both remifentanil and lidocaine.RESULTS:
There was a significantly lower incidence of microemulsion propofol injection pain (severity 2 or more) in the combination group (12.5%) than in the remifentanil and lidocaine groups (90% and 65%, respectively, P < 0.05). The incidence of moderate pain disappeared completely in the combination group (0%) compared to that in the remifentanil and lidocaine group (32.5% and 20%, respectively, P < 0.05). Severe pain did not appear in any of the three groups. There were no complications on the injection site in the lidocaine alone and combination groups.CONCLUSIONS:
The combination of microemulsion propofol premixed with lidocaine after a pretreatment with remifentanil was more effective in reducing the incidence of pain upon the injection of microemulsion propofol than either treatment alone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Propofol
/
Incidence
/
Anesthetics, Intravenous
/
Anesthesia
/
Lidocaine
Type of study:
Incidence study
/
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS